KLK3 and Familial prostate cancer: The median PSA level of patients with Gleason score 5 + 3 prostate cancer was 13.4 ng/ml (IQR 8.8–26.8 ng/ml), significantly higher than for men with Gleason score 3 + 5 (10.0 ng/ml; IQR 7.4–15.0 ng/ml; P = 0.05) and Gleason score 4 + 4 (8.9 ng/ml; IQR 6.9–16.0 ng/ml; P = 0.03).