CHRNA7 and early-onset autosomal dominant Alzheimer disease: High expression levels of α7 nAChR in the hippocampus, cerebral cortex, and several subcortical limbic regions suggest its contribution to higher brain functions, such as cognition, attention, memory, and sensory-gating 2, while impaired α7 nAChR signalling has been implicated in cognitive deficits associated with Alzheimer’s disease and schizophrenia1,4,5.