RNF213 and multiminicore myopathy: RNF213 was first identified as a susceptibility gene for MMD, but clearly RNF213 p.Arg4810Lys is involved in various patterns of intracranial artery stenotic phenotypes including ICAS, which suggests that RNF213 p.Arg4810Lys is involved in some complex mechanism affecting intracranial artery remodeling.