MBD2 and neoplasm: Given the central role of the H3K9me3 mark in senescence, we therefore asked, in turn, whether overexpression of two structurally unrelated H3K9me3-active demethylases, namely LSD1 (a.k.a. AOF2 or KDM1A) and JMJD2C (a.k.a. GASC1 or KDM4C), which we recently found to cancel OIS in melanomagenesis45, and which were detected at elevated levels in numerous tumor entities46–51, might also counter TIS.