Moreover, a high endogenous H3K9 demethylase status, among others composed of LSD1 and JMJD2C expression levels, not only predicted senescence restoring-susceptibility to the LSD1 inhibitor 2-PCPA-1a but equally to the JMJD2 inhibitor IOX1, while neither inhibitor enhanced ADR-inducible senescence in lymphomas with low endogenous H3K9me3 demethylase status (Supplementary Fig. 4f). This evidence concerns the gene KDM4A and lymphoma.