Specifically, we generated a signature named “SUVARness” (in scientific proximity to the term “BRCAness” invented for BRCA1/2 wild-type tumors that share molecular features of BRCA-mutant malignancies52, albeit composed here as a transcriptional signature), consisting of TIS upregulated genes, thus marking the conceptual opposite of the senescence-compromising Suv39h1 deficiency in lymphoma (Fig. 5a). Here, BRCA1 is linked to lymphoma.