As observed for mice bearing Suv39h1−;bcl2 lymphomas, those carrying control;bcl2 lymphomas engineered to stably overexpress either LSD1 or JMJD2C presented with very modest senescence induction, no significant enhancement of the H3K9me3-positive cell fraction, and a dramatically shortened OS after CTX therapy when compared to the respective vector control group, thus further underscoring the importance of an effective H3K9me3-governed senescence response for long-term disease control (Fig. 4b, c, Supplementary Fig. 4c). This evidence concerns the gene KDM1A and lymphoma.