In contrast, initiated by a single myc transgene, it is probably exactly this broad spectrum of early to rather mature B-cell lymphomas and their diverse secondary hits which accounts for a heterogeneity in the Eμ-myc model that seems to recapitulate at least some critical features of the heterogeneous DLBCL transcriptomes40,54. Here, MYC is linked to B-cell non-Hodgkin lymphoma.