Though, the vast majority of these cells scored Ki67+/H3K9me3− by co-immunostaining—in stark contrast to the virtually Ki67-negative but H3K9me3-positive, hence, senescent splenic lymphoma residues in the control group, indicating not only a massive drop in overall tumor burden, but an important qualitative state switch of the remaining Suv39h1-proficient LC (Fig. 3e). This evidence concerns the gene SUV39H1 and neoplasm.