MBD2 and lymphoma: Indeed, we found TIS much weaker in control lymphomas with globally high expression levels of H3K9-active demethylases, while the senescence response, and, accordingly, the fraction of H3K9me3-positive cells detected by immunostaining could be restored to an extent otherwise seen in low-level H3K9 demethylase expressers by treatment with the LSD1 inhibitor 2-PCPA-1a in vivo (Fig. 4d, Supplementary Fig. 4e).