Therefore, we performed additional in vitro experiments based on the two best 5-protein models (which shared TYMP, RRM1, UPP1, and UCK1 and contained either PPAT or UCK2) using two CRC and two leukemia cell lines that are predicted to be sensitive or resistant to 5FU (Fig. 4g). The gene discussed is RRM1; the disease is colorectal carcinoma.