More markedly, the level of NGFR was even much higher in ALDH-high MIC cells than in ALDH-low MIC cells in both of the SK-MEL-147 and SK-MEL-103 cell lines after sorting ALDH-positive spheroid-enriched melanoma cells as described in the “Materials and Methods”25,26 (Fig. 1c), which we called MIC-147 and MIC-103 cells, respectively, in this manuscript. This evidence concerns the gene LDHA and melanoma.