EPAS1 and cancer: Analysis of primary and metastatic HIF‐1α or HIF‐2α levels in a total of ≈9,300 images across two different models of advanced cancer (colon and breast) revealed that MTD chemotherapy can selectively induce HIF‐1α in primary tumors and established liver or lung metastases, an effect that was offset by LDM monotherapies and/or doublet regimens.