Furthermore, HIF‐1α induction by doublet LDM cyclophosphamide + MTD capecitabine was not due to differences in tumor volume, since luminescence plots displayed comparable slopes and absolute values at endpoint (Appendix Fig S2A), overall signal doubling times of ≈15 days (Appendix Fig S2B), and comparable cross‐sectional areas among treatments (Appendix Fig S2C and D); likewise, no significant correlations were observed among HIF‐1α, HIF‐2α and CA9 expression (Appendix Fig S3A–C). Here, CA9 is linked to neoplasm.