Since intra‐metastatic HIF‐1α and HIF‐2α levels were not correlated in the lung (Appendix Fig S5D), we suggest that these data indicate a site‐specific effect wherein MTD chemotherapy selectively stimulates HIFα paralog induction in experimental colon adenocarcinomas (i.e., HIF‐1α: liver and HIF‐2α: lung), an effect that was selectively offset by specific LDM regimens. This evidence concerns the gene EPAS1 and colon adenocarcinoma.