Since both DNA hypomethylation and overexpression of DCAF4L2 were significantly correlated with clinicopathological parameters of N samples reflecting the severity of inflammation (NAS score and necroinflammatory grade), it appears that DCAF4L2 abnormalities can be induced by the inflammatory process during the precancerous NASH stage. Here, DCAF4L2 is linked to metabolic dysfunction-associated steatohepatitis.