Since inflammatory cytokines can disturb the DNA methylation status of specific genes (Rokavec et al. 2016), it is feasible that expression alterations due to changes in the DNA methylation of NF-ΚB-related genes occur during the inflammatory process of NASH, thus promoting NF-KB signaling-related cell proliferation, tumorigenesis and epithelial–mesenchymal transition (EMT) (Kaltschmidt et al. 2019). This evidence concerns the gene NFKB1 and metabolic dysfunction-associated steatohepatitis.