PEComas are characterized by immunoexpression of both myoid (desmin, SMA, muscle-specific-actin, muscle myosin, and calponin) and melanocytic (HMB-45, Melan-A/MART-1, tyrosinase, and MiTF) markers (Folpe et al., 2005, Conlon et al., 2015, Bennett et al., 2018, Bonetti et al., 1997, Thway and Fisher, 2015). Here, MLANA is linked to neoplasm with perivascular epithelioid cell differentiation.