Since the first anti-TNFα biologic, infliximab, was approved in 1998 for CD,13 several other biologic agents have been approved for use in IBD treatment, including alternative anti-TNFα agents (e.g. adalimumab in UC and CD, and golimumab in UC only14,15) and biologics with other mechanisms of action, such as antibodies against interleukin (IL)-12 and IL-23 (e.g. ustekinumab in CD16) or integrin inhibitors (e.g. vedolizumab in UC and CD17). The gene discussed is TNF; the disease is inflammatory bowel disease.