Around 20% of the study population did not receive any treatment intensification at all.7 The result of these factors is that around 70% of adults with diabetes on insulin have difficulty achieving adequate glycemic control (AIC <7%).8 When glucose levels are sub-optimally controlled, people are at increased risk for diabetes-related complications that include damage to the eyes, kidneys, nerves, and cardiovascular system. This evidence concerns the gene INS and diabetes mellitus.