The average level of HbA1c for patients treated with insulin has not improved for decades, and frequent titration of insulin dosage is crucial to maintain optimal glycemic control and avoid hypoglycemia.15 Optimizing insulin dosing among insulin-reliant individuals with T2D has been shown to be a very effective means of lowering HbA1c and achieving clinical targets.14,16. This evidence concerns the gene INS and type 2 diabetes mellitus.