Our study found that the two PNPLA2 polymorphisms rs28633403 and rs1138714 showed significant association with DKD, and both SNPs are located in noncoding regions of PNPLA2. Previous studies have shown that most disease-associated SNPs are located in the noncoding region, suggesting that they may play a regulatory role in phenotypes [34]. The gene discussed is PNPLA2; the disease is diabetic kidney disease.