The genotype and allele frequencies of PNPLA2 rs28633403 (A>G) and rs1138714 (A>G) were significantly different in the DKD and T2DM groups (rs28633403: genotype, P = 0.017; allele, P = 0.015; rs1138714: genotype, P = 0.029; allele, P = 0.018). Here, PNPLA2 is linked to diabetic kidney disease.