Accordingly, genetic risk variants identified as ancestry-specific signals through fine mapping of causal variants (AGMO-rs73284431, VT11A-rs17746147, and ZRANB3), and the transferable genetic risk variants (TCF7L2), are reported to act through beta-cell dysfunction to confer the risk of T2DM [36, 37]. The gene discussed is TCF7L2; the disease is type 2 diabetes mellitus.