CXCL12 and gastric adenocarcinoma: Based on tumor purity, we ascertained that most cytokines are secreted by TAMs and M2 macrophages, and marker sets have significant correlations with CDH11 in STAD, with examples including CCL-2, TGFB1, CXCL12, and MPP2 of TAMs and IL-10, IL1R1, CD163, and MRC1 of M2 phenotype (P < 0.0001; Figure 8).