There were consistently 0 upregulated (Figure 1(f)) and 2 downregulated (Figure 1(g)) genes, including ACSBG1 and BCAT2, among GSE10432 (SEB-1 sebocytes incubated with isotretinoin for 72 hours), GSE10433 (acne patients treated with isotretinoin for 1 week), and GSE11792 (acne patients treated with isotretinoin for 8 weeks). The gene discussed is ACSBG1; the disease is acne.