In addition, our results from the Western blot analysis showed that after the transfection of siNEIL1 in the human CRC cells, the Bax expression levels were significantly increased while the Bcl-2 expression levels were significantly decreased, resulting in the Bax/Bcl-2 balance moving towards apoptosis (Figure 2(d)). The gene discussed is BAX; the disease is colorectal carcinoma.