HLA-DQB1 and chronic obstructive pulmonary disease: Qian et al. [46] found that the lnc-HLA-DQA1-5 (ENST00000419852, HLA-DQB1-AS1) expression in patients with smoking chronic obstructive pulmonary disease (COPD) was increased compared to controls and speculated that it played a crucial role in the pathogenesis in smoking COPD.