PLA2G6 and neurodegeneration with brain iron accumulation 2A: The loss of iPLA2β function is associated with functional and structural abnormalities; this loss of function is most notable in neurons, where the damaged membranes accumulate as spheroids leading to early cell death and neurodegeneration.9, 10 Mutations in PLA2G6 have been associated with a variety of neurodegenerative conditions including INAD, atypical NAD, and young‐onset Parkinson's disease.