INAD is an autosomal recessive disorder due to pathological variations in both copies of the PLA2G6 gene (chromosome 22q13.1) which encodes a phospholipase (iPLA2β [MIM 603604]).4, 6, 7 This enzyme performs a critical housekeeping function in all cell membranes, where polyunsaturated fatty acids (PUFAs) are prone to lipid peroxidation (LPO).8 Membrane repair is most critical in conditions of high oxidative stress, as found in the mitochondria of highly metabolic tissues. The gene discussed is PLA2G6; the disease is neurodegeneration with brain iron accumulation 2A.