Compared with the CON, PRRSV infection (EASE score < 0.05) up-regulated the expression of genes involved in the following pathways: primary immunodeficiency, hematopoietic cell lineage, dilated cardiomyopathy, T cell receptor signaling pathway, complement and coagulation cascades, systemic lupus erythematosus, PPAR signaling pathway, and cytokine-cytokine receptor interaction, but down-regulated (EASE score < 0.05) the expression of genes related to pathways in cancer, MAPK signaling pathway, and TGF-beta signaling pathway (Fig. 5a). This evidence concerns the gene PPARA and inborn error of immunity.