TP53 and neoplasm: These changes are point mutations in protooncogene k-ras and DNA hypomethylation - DNA loss on the side of the tumor inhibitor gene (APC: Adenonatous polyposis coil gene in the long arm of chromosome 5), allelic loss on the tumor-gene inhibitor on the chromosome 18q and allelic loss in chromosome p17, which is associated with p53 mutation [10].