At the same time, there are recent data indicated that enterotoxigenic B. fragilis strains (ETBF) producing B. fragilis toxin (BFT) are associated with CRC, especially in the patients with precancerous lesions and initial carcinogenic lesions (40) and with ulcerative colitis, especially in the patients with diarrhea symptoms (41). This evidence concerns the gene PITX1 and colorectal carcinoma.