Moreover, our results indicate that inhibiting MSK1 by SB-747651A dramatically decreases the rates of alcohol-increased cell growth and colony formation (Figures 6, 7(a), and 7(b)), as Brf1 is overexpressed in HCC tumor tissues of animals and humans (Figures 7(c)–7(e)). The gene discussed is BRF1; the disease is hepatocellular carcinoma.