Our studies indicate that Brf1 expression, either its mRNA (Figure 7(c)) or protein (Figure 7(d)), is significantly increased in the liver tumor tissue of mouse HCC (#1 in Figures 7(c) and 7(d)), compared with nontumor tissues (#2 and #3 in Figures 7(c) and 7(d)). Here, BRF1 is linked to hepatocellular carcinoma.