Our study shows that ethanol enhances Brf1 expression and Pol III gene transcription in nontumor hepatocytes, such as PMHs and AML-12 cells, and the tumor liver cell, HepG2-ADH cells (Figure 1), while the induction of Brf1 and Pol III genes in tumor hepatocytes-HepG2-ADH cells is much higher than that in nontumor hepatocytes, PMHs and AML-12 cells. This evidence concerns the gene BRF1 and neoplasm.