In this study, we sought the replication of 47 previously GWAS-implicated CAD risk variants among Europeans in the Pakistani population and found a significant association of five of the variants with coronary stenosis (PLG/rs4252120, KIAA1462/rs2505083, SLC22A3-LPAL2-LPA/rs2048327, SORT1/rs602633, and UBE2Z/rs46522). This evidence concerns the gene JCAD and coronary artery disorder.