The data from all subjects, including all 51 SLE patients and 38 HCs in screening stage and validation stage, demonstrated that the mRNA levels of METTL3, WTAP, ALKBH5, and FTO in peripheral blood were significantly lower in SLE patients than those in HCs (all P < 0.050) (Figure 2). The gene discussed is FTO; the disease is systemic lupus erythematosus.