A multicenter randomized open-label phase 2 trial (ChiCTR2000029308) showed that triple antiviral therapy with interferon beta-1b, lopinavir-ritonavir, and ribavirin was safe and superior to lopinavir-ritonavir alone in alleviating symptoms, suppressing shedding of SARS-CoV-2, and facilitating discharge of patients with mild to moderate COVID-19 168. This evidence concerns the gene IFNB1 and COVID-19.