Rab22a-NeoF1 fusion protein has 186aa comprising the 1-38aa of Rab22a (Rab22a1-38) and the 39-186aa encoded from the inverted intron of DOK5. The Rab22a1-38 plays a decisive role in driving osteosarcoma lung metastasis by activating RhoA through binding to SmgGDS607 via Arg4 (R4) and Lys7 (K7) 8. The gene discussed is RAB22A; the disease is osteosarcoma.