Therapy options for PC have evolved over the last decade since the advent of next generation androgen deprivation therapy (ADT) for metastatic castration resistant PC (mCRPC) by androgen receptor (AR) signaling inhibition (abiraterone and enzalutamide) in addition to taxane based chemotherapy (docetaxel and cabazitaxel), Radium-223 and Sipuleucal-T. Here, AR is linked to pachyonychia congenita.