A portion of tumor cases were highly co-expressed B7-H3 and CD70, including 2 of 5 melanoma cases, 19 of 62 lung cancer cases, 16 of 64 kidney cancer cases, 5 of 15 liver cancers cases, 22 of 62 breast cancer cases, 13 of 32 esophageal cancer cases, 17 of 32 colon cancer cases and 7 of 33 glioma cases (Table S1), while there was no detectable B7-H3 or CD70 expression in normal tissues. The gene discussed is CD276; the disease is malignant colon neoplasm.