Further, based on the RNA-seq analysis from the Cancer Genome Atlas (TCGA) and Oncomine database, we found transcripts of CD70 or B7-H3 were up-regulated in multiple cancer types which includes not only the tumor types mentioned above but also cervical, neck, pancreatic cancer as well as leukemia and lymphoma (Figure 1B, S2-3). Here, CD276 is linked to familial pancreatic carcinoma.