To further clarify GLP-2 regulated intestinal epithelial proliferation and apoptosis through decreasing exosomal miR-125a/b, miR-125a inhibitor-loaded primary intestinal myofibroblasts exosomes or NC inhibitor-loaded primary intestinal myofibroblasts exosomes were delivered to SBS rats. The gene discussed is GCG; the disease is macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss.