Conversely, the tumor incidence in LSL-hMYH9; Atp4b-cre; Tff1-/- mice was significantly enhanced (16/20, 80%) and the tumor size was larger, when compared with LSL-hMYH9; Tff1-/- mice (9/20, 45%; Figure 7C, S21B). Here, TFF1 is linked to neoplasm.