MYC and hepatocellular carcinoma: In conclusion, in this study, we identified a novel lncRNA termed lncCSMD1 that is upregulated in HCC tissues and positively correlated with metastasis and poor prognosis of HCC patients; in cell and animal models, we validated the oncogenic role of lncCSMD1 in HCC; mechanistically, we demonstrated that lncCSMD1 specifically binds MYC protein and maintains its stability by reducing the ubiquitination of MYC, leading to activation of MYC downstream signaling pathway in HCC cells.