MYC and hepatocellular carcinoma: To understand the molecular mechanisms underlying the oncogenic role of lncCSMD1 in HCC, we first explored gene expression profile and cellular signalings regulated by lncCSMD1 with commercial microarray, GSEA and RT-PCR analysis, and found that lncCSMD1 enhances MYC protein expression and activates MYC signaling without affecting its mRNA expression at the transcriptional level, implying that MYC and its signaling play an important role in lncCSMD1 mediated hepatocarcinogenesis.