The reduction in M2 macrophages in our 4T1 breast tumors treated with αvβ3-MI3-PD NP could be explained, theoretically, either by direct effects on αvβ3+ macrophages by MI3, as shown in vitro, or by indirect effects of MYC inhibition in the αvβ3+ 4T1 cancer cells. This evidence concerns the gene MYC and cancer.