MYC and MAX RNA were detected in circulating breast cancer monocytes (KRT7+, CD11b+, CSF1R+), whole breast cancer tissue (KRT7+, CD11b+, CSF1R+), and isolated breast cancer tumor infiltrating macrophages (KRT7 negative or low, CD11b+, CSF1R+), supporting a potential role for MYC in human TAMs (Figure 4A). This evidence concerns the gene MYC and breast cancer.