IL1A and periodontitis: Recently, Cantore et al. confirmed these data by molecular analyses reporting a statistically significant correlation between the severe form of periodontitis and the presence of IL-1α (+4845) and IL-1β (+3954) single nucleotide polymorphisms (SNPs) [166], refuting previous studies that identified a marked contribution of IL-1 in development of periodontitis and that refused it as essential on disease risk [167].