This finding explained previously stresses the role of CD44 as a homing receptor for distant tissue compartments, a view that is in line with the CD44 expression being associated with cell motility through linking with putative actin-binding proteins [33], and the difference in our report could be explained by more visceral plus bone metastasis that could be attributed to the delay in seeking medical advice of patients in our region till they have more advanced disease with disseminated visceral metastasis. This evidence concerns the gene CD44 and bone metastasis.