We previously identified upregulation of FcγRIIb (CD32b) in LSK (lin−;c-kit+,Sca-1+) cells from transgenic SCLtTA/Bcr-Abl CML-CP mice (2.8-fold, p < 0.05) by microarray analysis [26], and here we first confirmed upregulation of the receptor by real-time quantitative PCR (qRT-PCR) (FcγRIIb) and FACS analysis (CD32b) in these malignant LSK cells (Fig. 1a). Here, FCGR2B is linked to chronic myelogenous leukemia, BCR-ABL1 positive.