TNFRSF8 and neoplasm: Semi-quantitative scoring of CD30 expression in xenograft tumours by IHC showed a reduction in CD30 stain intensity from a median score of 9.0 (range 7.5–9.0) for vehicle control treated mice, to 3.0 (range 1.0–4.0) for 1 mg/kg BV-treated mice and 1.0 (range 1.0–4.0) for 3 mg/kg BV-treated mice compared to vehicle control (P < 0.05, for comparison of control vs 3 mg/kg treatment) (Fig. 2i).