CD8A and neoplasm: Spatiotemporal analyses of the immune response have previously highlighted global depression of the T-cell response in the central tumour and invasive margin as stage increases, whilst inversely B-cell expression increases.2 Our study found expression of T-helper (CD4) to correlate strongly with CD3- and CD8-expressing cells quantified in the central tumour, when the dichotomised density of CD4-expressing cells was combined with dichotomised densities of CD3- and CD8- expressing cells.