Hence, HPV+ tumours show an upregulation of CDKN2A as a consequence of negative feedback loop to control cell cycle, from pRb loss.40 In addition, CX3CL1 and MYB shared common alteration (mRNA upregulation) both in WT OP and HPV+ OP, leading to a positive regulation of transforming growth factor beta production. The gene discussed is RB1; the disease is neoplasm.