A previous comprehensive genomic study on the same TCGA cohort provided fundamental insights into the correlation between mutational profile of TP53 and HNSCC; however it did not take into consideration the anatomical sublocalisation of tumours in the HNSCC area, in which HPV-positive oropharynx subgroup frequently exhibits wild-type TP53 and favourable prognosis.32 After integrating the survival analysis according to the subsite of HNSCC onset, mutated TP53 resulted to be an independent prognostic factor for overall and disease-free survival only in OP. Here, TP53 is linked to neoplasm.