TRPM7 and non-small cell lung carcinoma: We observed a remarkable decrease in global O-GlcNAcylation in NSCLC cells upon treatment with the TRPM7 inhibitor 2-APB (>10 μM) (Fig. 3a) and upon TRPM7 knockdown (Fig. 3b), suggesting the functional linkage between TRPM7-mediated cell motility and O-GlcNAcylation.