Among those, TRPM7 has earlier been shown to be aberrantly expressed in lung adenocarcinoma and squamous cell lung carcinoma and linked to cancer stem cell subpopulation and its carcinogenic potential.13 Orai1, through its interaction with ER Ca2+ sensor protein STIM1 following depletion of internal Ca2+ store, activated store-operated calcium entry at the plasma membrane.10,14 Using bioinformatics database, we examined the association between TRPM7, ORAI1 and STIM1 messenger RNA (mRNA) expression and clinical prognosis in non-small cell lung cancer (NSCLC). This evidence concerns the gene ORAI1 and cancer.