TRPM7 and lung cancer: In lung cancer, a frequent gene amplification or copy number gain of MYC was detected in small cell lung cancer in up to 40% of all cases and in NSCLC in human tumour tissues and various animal models.49MYC gain is associated with lymph node metastasis and is believed to be a metastasis gene for NSCLC.37 Like Cav-1, c-Myc was found in this study to be a favourable target of TRPM7 and O-GlcNAcylation in controlling NSCLC cell motility.