ORAI1 and cancer: Altered calcium signalling often involves an aberrant expression, cellular localisation and function of Ca2+ channels, contributing towards specific hallmarks of cancers, such as uncontrolled growth and resisting cell death.4,6 We first performed survival analysis in human NSCLC patients using Kaplan–Meier plotter based on mRNA expression of TRPM7, ORAI1 and STIM1 to assess the clinical significance of these major channels.