Most importantly, hyper-O-GlcNAcylation by thiamet G was able to rescue the reduced migratory phenotype upon TRPM7 inhibition (Fig. 4a, b), thereby uncovering the novel regulation of NSCLC cell motility through TRPM7/O-GlcNAc regulatory axis. The gene discussed is TRPM7; the disease is non-small cell lung carcinoma.