We also acknowledge that this study is limited by the relatively modest number of events (i.e., new tumour event, death) for the different cohorts (ER+/HER2-: 97 events in 552 patients; TAM: 24 events in 172 patients; AI: 32 events in 210 patients) due to the relatively short follow-up time. This evidence concerns the gene ESR1 and neoplasm.