This suggests that NFAT5 might also be involved in embryonic formation and development, liver detoxification, and tumor metastasis.51–54 Our functional studies revealed that NFAT5 targets JMJD2B, is selectively activated because of ETBF co-culture, and can biologically modulate CRC stemness in vitro and in vivo. This evidence concerns the gene KDM4B and neoplasm.