KDM4B and colorectal carcinoma: Compelling evidence indicates that JMJD2B is overexpressed in human CRC tissue, and that it is implicated in various cellular processes, including apoptosis, cell cycle, invasion, DNA damage response, and metabolism to promote CRC progression.44–47 Furthermore, JMJD2B plays a critical role in self-renewal of ESCs and iPSC generation.48,49 Consequently, we hypothesized that ETBF promotes CRC stemness via JMJD2B.