GSEA suggested that most of the genes in subjects before bariatric surgery were mainly enriched in the toll-like receptor signalling pathway, the NOD-like receptor signalling pathway, cytokine-cytokine receptor interactions, the chemokine signalling pathway, the B cell receptor signalling pathway, the Jak-STAT signalling pathway, which have collectively been confirmed as essential mechanisms in inflammation of AT, thus contributing to the pathogenesis of insulin resistance. The gene discussed is SOAT1; the disease is ataxia telangiectasia.