The NOD-like receptor (NLR) protein family (NLRP3) in macrophage could be activated by lipid spill from necrotic adipocytes such as following the interplay of reactive oxygen species (ROS), saturated fatty acids, adenosine triphosphate, ceramides and dysfunction of the mitochondrial system, which is a predominant determinant in inflammation in AT and has critical functions in insulin resistance [47,48]. Here, NLRP3 is linked to Insulin resistance.