Among the dysregulated FOXK1/K2 targets by mutant ASXL1 are multiple tumor suppressors: VHL mutations and promoter hypermethylation play a crucial role in the development of AML (Labno-Kirszniok et al., 2013; Gossage et al., 2015; Moura et al., 2018); SOCS1 and SOCS2 are associated with dysregulation of cell growth, cancer-associated inflammation, and cell death induced by multiple cytokines and hormones (Duncan et al., 2017; Jiang et al., 2017); TXNIP plays an important role in glucose uptake and redox homeostasis (Waldhart et al., 2017). Here, VHL is linked to acute myeloid leukemia.