Among the genes whose expression was down-regulated by C-terminally truncated ASXL1 mutation or knocking-down of FOXK1 or FOXK2 are multiple tumor suppressors, including Von Hippel-Lindau syndrome (VHL), thioredoxin interacting protein (TXNIP), suppressor of cytokine signaling 1 and 2 (SOCS1, SOCS2), membrane associated guanylate kinase 1 (MAGI1) and zinc finger protein 516 (ZNF516) (Fig. 4A). The gene discussed is SOCS1; the disease is neoplasm.