Nucleophosmin 1 (NPM1) is frequently mutated in AML and exerts multifunctions in the regulation of centrosome duplication, ribosome biogenesis, genomic stability, histone chaperone function, and transcription (Verhaak et al., 2005; Heath et al., 2017); GATA binding protein 1 (GATA1) is a DNA-sequence specific TF which regulates erythroid development by controlling the fetal-to-adult hemoglobin switch, and correlates with the degree of myeloid phenotypic changes in Npm1/Flt3-ITD mice (Sportoletti et al., 2019). The gene discussed is NPM1; the disease is acute myeloid leukemia.