GCC was first described by Gagne in 1969 [3] and is known by many names including adenocarcinoid, mucinous carcinoid, microglandular GCC, amphicrine neoplasm, mucin-producing neuroendocrine tumor, or carcinoma and crypt cell carcinoma because this lesion has unique mixed endocrine-exocrine features [6]. The gene discussed is MUC5AC; the disease is goblet cell carcinoma.