In order to elucidate if the beneficial effect of LAV-BPIFB4 in vitro might be reproducible also in vivo in HD, manifested (7 weeks old) R6/2 female mice and age-matched control littermates were injected into femoral arteries with single dose of 1 × 1013 GC/kg of adeno-associated viral (AAV)-GFP, AAV-WT-BPIFB4, or AAV-LAV-BPIFB4 vectors and motor function was then evaluated. Here, BPIFB4 is linked to Huntington disease.