From the mechanistic point of view, administration of AAV-LAV-BPIFB4 was associated with reduced area of mHtt aggregates in the striatum of HD mice (Fig. 4e, f) and with restoration of normal levels of brain derived neurotrophic factor (BDNF) in the cortex (Fig. 4g, h). The gene discussed is BDNF; the disease is Huntington disease.