Even though the mechanism by which LAV-BPIFB4 induces SDF-1 expression is still unknown, the relevance covered by the SDF-1 in myeloid cell differentiation, tissue repair and stem cell mobilization, might in part explain the beneficial effect achieved by LAV-BPIFB4 gene therapy in the context of HD. The gene discussed is CXCL12; the disease is Huntington disease.