However, the proportion of activated SSCs (Pax7+MyoD+), Ki67-positive cells, and OD 450 values in the DM1-13-3 group were higher than those in the DM1-03 group, but lower than those in the DM1-04 group, indicating that TALEN genome modification targeting CTG repeats promoted the proliferation of DM1 SSCs, but could not restore the proliferation level of normal human SSCs (DM1-04). Here, MKI67 is linked to myotonic dystrophy type 1.