Besides, treatment with tubastatin A or ACY-1215 or CAY10603, selective HDAC6 inhibitors, were reported to abrogate temozolomide resistance by decreasing and inactivating EGFR protein, thus reducing glioblastoma clonogenicity and migration capacities, accelerating temozolomide-induced apoptosis, and finally reversing the malignant phenotype [192]. The gene discussed is HDAC6; the disease is glioblastoma.