MTHFR and coronary artery disorder: For ESR1(rs9340799) SNP, the variant G-allele was adding about 1.4 folds of risk; for MTHFR (rs1801133) SNP, T-allele was adding 5.3 folds risk and for MS (rs185087) SNP, the G-allele was conferring nearly 1.5 folds risk towards the susceptibility of CAD.