Regarding SNPs in MTHFR gene, haplotype T-G provided 4.7 fold risk [OR = 4.71 (2.270–9.762), p = 5.18e-006] of CAD development while haplotype C-G was found attributing 1.7 fold protection (1/0.57) towards the disease [OR = 0.57 (0.42–0.77), p = 0.0002]. Here, MTHFR is linked to coronary artery disorder.