Among the m6A regulators, previous studies indicated that the eraser ALKBH5 can induce breast cancer stem cell and glioblastoma stem-like cell proliferation and tumor initiation, [22] the writers METTL3 and METTL14 were reported to enhance glioblastoma growth and suppress Liver cancer metastasis, [23–25] the reader YTHDF1 and YTHDF2 induce cancer cell proliferation in colon cancer and lung oncogenic effects [26, 27]. The gene discussed is METTL3; the disease is malignant colon neoplasm.